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Although GLP-1 medications have transformed obesity treatment, there remains a significant need for rigorous data examining how these therapies affect fertility and reproductive function in this population. The RESTORE study is currently evaluating semaglutide treatment in girls and women with PMOS and obesity, with the overarching goal of determining whether weight loss and metabolic improvements can restore ovulation and improve reproductive outcomes

doi:10.1042/bj2860383

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The mechanism of action involves binding to GLP-1 receptors found throughout the body, particularly in the pancreas, brain, and gastrointestinal tract

Semaglutides GLP-1R engagement activates the canonical Gs-cAMP-PKA-EPAC2 signalling cascade , producing glucose-dependent insulin secretory potentiation in beta cells, central appetite suppression through hypothalamic and brainstem GLP-1R-mediated anorexigenic neurocircuit activation, glucagon suppression in alpha cells, gastric emptying inhibition through vagal GLP-1R pathways, and cardioprotective biology through direct cardiac GLP-1R signalling